Semisynthesis and Inhibitory Effects of Solidagenone Derivatives on TLR-Mediated Inflammatory Responses

Semisynthesis and Inhibitory Effects of Solidagenone Derivatives on TLR-Mediated Inflammatory Responses

A series of nine derivatives (<b>2</b>–<b>10</b>) were prepared from the diterpene solidagenone (<b>1</b>) and their structures were elucidated by means of spectroscopic studies. Their ability to inhibit inflammatory responses elicited in peritoneal macrophages by...

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Bibliographic Details
Main Authors: Irene Cuadrado, Ángel Amesty, Juan Carlos Cedrón, Juan Carlos Oberti, Ana Estévez-Braun, Sonsoles Hortelano, Beatriz de las Heras
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Molecules
Subjects:
solidagenone derivatives
diterpenes
inflammation
TLR4
molecular docking
Online Access:https://www.mdpi.com/1420-3049/23/12/3197

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