Corneal ulceration associated with Nivolumab use

Corneal ulceration associated with Nivolumab use

Purpose: To describe a case of corneal ulceration associated with Nivolumab use. Observations: An 80-year-old woman treated with Nivolumab for metastatic melanoma developed an intractable corneal ulcer in her left eye, refractory to all therapies – including surgery to cover the ulcer with a conjunc...

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Main Authors: Jack S. Parker, Wyatt Feagin, Christopher Wang, Marius Heersink, John S. Parker
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:American Journal of Ophthalmology Case Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2451993618301038
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spelling doaj-be6d3c5c3eef4b4b8e6253f430edfbf02020-11-25T00:53:13ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362019-06-01142627Corneal ulceration associated with Nivolumab useJack S. Parker0Wyatt Feagin1Christopher Wang2Marius Heersink3John S. Parker4Parker Cornea, 1720 University Blvd Suite 503, Birmingham, AL, 35233, USA; Netherlands Institute for Innovative Ocular Surgery (NIIOS), Laan op Zuid 88 - 3071 AA Rotterdam, Rotterdam, NL, the Netherlands; Corresponding author. Parker Cornea, Birmingham, AL, USA.Alabama Eye Ophthalmology Associates, 1009 Montgomery Hwy #200, Birmingham, AL, 35216, USAAlabama Oncology Brookwood, 2022 Medical Center Drive, Suite 628, Birmingham, AL, 35209, USAUniversity of Alabama at Birmingham School of Medicine, 1670 University Blvd, Birmingham, AL, 35233, USAParker Cornea, 1720 University Blvd Suite 503, Birmingham, AL, 35233, USAPurpose: To describe a case of corneal ulceration associated with Nivolumab use. Observations: An 80-year-old woman treated with Nivolumab for metastatic melanoma developed an intractable corneal ulcer in her left eye, refractory to all therapies – including surgery to cover the ulcer with a conjunctival flap – until topical prednisolone acetate was tried, which was curative. Conclusions and importance: Nivolumab use may be associated with a form of steroid-responsive corneal ulceration. Keywords: Cornea, Corneal ulcer, Nivolumab, Opdivo, Peripheral ulcerative keratitishttp://www.sciencedirect.com/science/article/pii/S2451993618301038
collection DOAJ
language English
format Article
sources DOAJ
author Jack S. Parker
Wyatt Feagin
Christopher Wang
Marius Heersink
John S. Parker
spellingShingle Jack S. Parker
Wyatt Feagin
Christopher Wang
Marius Heersink
John S. Parker
Corneal ulceration associated with Nivolumab use
American Journal of Ophthalmology Case Reports
author_facet Jack S. Parker
Wyatt Feagin
Christopher Wang
Marius Heersink
John S. Parker
author_sort Jack S. Parker
title Corneal ulceration associated with Nivolumab use
title_short Corneal ulceration associated with Nivolumab use
title_full Corneal ulceration associated with Nivolumab use
title_fullStr Corneal ulceration associated with Nivolumab use
title_full_unstemmed Corneal ulceration associated with Nivolumab use
title_sort corneal ulceration associated with nivolumab use
publisher Elsevier
series American Journal of Ophthalmology Case Reports
issn 2451-9936
publishDate 2019-06-01
description Purpose: To describe a case of corneal ulceration associated with Nivolumab use. Observations: An 80-year-old woman treated with Nivolumab for metastatic melanoma developed an intractable corneal ulcer in her left eye, refractory to all therapies – including surgery to cover the ulcer with a conjunctival flap – until topical prednisolone acetate was tried, which was curative. Conclusions and importance: Nivolumab use may be associated with a form of steroid-responsive corneal ulceration. Keywords: Cornea, Corneal ulcer, Nivolumab, Opdivo, Peripheral ulcerative keratitis
url http://www.sciencedirect.com/science/article/pii/S2451993618301038
work_keys_str_mv AT jacksparker cornealulcerationassociatedwithnivolumabuse
AT wyattfeagin cornealulcerationassociatedwithnivolumabuse
AT christopherwang cornealulcerationassociatedwithnivolumabuse
AT mariusheersink cornealulcerationassociatedwithnivolumabuse
AT johnsparker cornealulcerationassociatedwithnivolumabuse
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