Specific inhibition of PI3Kδ/γ enhances the efficacy of anti-PD1 against osteosarcoma cancer

Specific inhibition of PI3Kδ/γ enhances the efficacy of anti-PD1 against osteosarcoma cancer

ABSTRACT: Impressive responses have been observed in patients with cancer treated with checkpoint inhibitory anti-programmed cell death-1 (PD-1) or anti-cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) antibodies through disinhibiting the immune system. However, tumors possess complex immunosupp...

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Bibliographic Details
Main Authors:	Xinge Shi, Xiqing Li, Hongqiang Wang, Zhenghong Yu, Yu Zhu, Yanzheng Gao
Format:	Article
Language:	English
Published:	Elsevier 2019-06-01
Series:	Journal of Bone Oncology
Online Access:	http://www.sciencedirect.com/science/article/pii/S221213741830099X

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