Asthmatic condition induced the activity of exosome secretory pathway in rat pulmonary tissues

• Main Authors: Asheed Almohammai, Reza Rahbarghazi, Rana Keyhanmanesh, Jafar Rezaie, Mahdi Ahmadi
• Format: Article
• Language: English
• Published: BMC 2021-04-01
• Series: Journal of Inflammation
• Subjects: Asthma; Exosome biogenesis; CD63; Inflammatory cytokines; Rats
• Online Access: https://doi.org/10.1186/s12950-021-00275-7

Abstract Background The recent studies highlighted the critical role of exosomes in the regulation of inflammation. Here, we investigated the dynamic biogenesis of the exosomes in the rat model of asthma. Results Our finding showed an increase in the expression of IL-4 and the suppression of IL-10 in asthmatic lung tissues compared to the control samples (p < 0.05). Along with the promotion of IL-4, the protein level of TNF-α was induced, showing an active inflammatory status in OVA-sensitized rats. According to our data, the promotion of asthmatic responses increased exosome biogenesis indicated by increased CD63 levels and acetylcholine esterase activity compared to the normal condition (p < 0.05). Conclusion Data suggest that the stimulation of inflammatory response in asthmatic rats could simultaneously increase the paracrine activity of pulmonary cells via the exosome biogenesis. Exosome biogenesis may correlate with the inflammatory response.