Summary: | Ichthyosis presents as cornification alterations characterized by hyperkeratosis and desquamation, where the skin acquires the appearance of fish scales, and are of genetic origin or associated with other diseases. The genetic and biochemical diversity of its etiopathogeny makes it essential to take into account the clinical and hereditary peculiarities of each ichthyosis. This facilitates the diagnostic decision as the basis for genetic counseling and follow-up of the sick patient. Some of the clinical variants of ichthyosis have been described accompanied by recurrent infections and atopic diathesis, an element that supports an associated immunoscore. Taking into account its scientific interest this study presents a clinical case with ichthyosiform dermatosis and cutaneous papillomavirus, who is assessed at the departments of immunology and genetics. The interdisciplinary assessment of the patient was of great value to achieve a more comprehensive view of the pathophysiology of his disease, which facilitated a better care and the subsequent genetic counseling to the patient and his family.
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