Biliverdin Reductase: a Target for Cancer Therapy?

Biliverdin Reductase: a Target for Cancer Therapy?

Biliverdin reductase (BVR) is a multifunctional protein that is the primary source of the potent antioxidant, bilirubin. BVR regulates activities/functions in the insulin/IGF-1/IRK/PI3K/MAPK pathways. Activation of certain kinases in these pathways is/are hallmark(s) of cancerous cells. The prote...

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Bibliographic Details
Main Authors: Peter eGibbs, Tihomir eMiralem, Mahin D Maines
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Pharmacology
Subjects:
Cell Cycle
Extracellular Signal-Regulated MAP Kinases
Heme Oxygenase-1
Oxidative Stress
Protein Kinase C
Biliverdin Reductase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00119/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00119/full

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