BZD9L1 sirtuin inhibitor as a potential adjuvant for sensitization of colorectal cancer cells to 5-fluorouracil

Background: This study aims to investigate the combination effect of a novel sirtuin inhibitor (BZD9L1) with 5-fluorouracil (5-FU) and to determine its molecular mechanism of action in colorectal cancer (CRC). Methods: BZD9L1 and 5-FU either as single treatment or in combination were tested against...

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Bibliographic Details
Main Authors: Yi Jer Tan, Yeuan Ting Lee, Sven H. Petersen, Gurjeet Kaur, Koji Kono, Soo Choon Tan, Amin M. S. Abdul Majid, Chern Ein Oon
Format: Article
Language:English
Published: SAGE Publishing 2019-09-01
Series:Therapeutic Advances in Medical Oncology
Online Access:https://doi.org/10.1177/1758835919878977

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