Sustained delivery of MMP-9 siRNA via thermosensitive hydrogel accelerates diabetic wound healing

Sustained delivery of MMP-9 siRNA via thermosensitive hydrogel accelerates diabetic wound healing

Abstract Excessive expression of matrix metalloproteinase 9 (MMP-9) impedes healing of diabetic chronic wounds, thus wound dressing that could effectively inhibit the expression of MMP-9 offers significant clinical translation for diabetic wound healing. Herein, a hybrid hydrogel dressing was develo...

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Bibliographic Details
Main Authors: Biyun Lan, Liming Zhang, Liqun Yang, Junfeng Wu, Na Li, Chenglin Pan, Xiaoyi Wang, Lexiang Zeng, Li Yan, Chuan Yang, Meng Ren
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Nanobiotechnology
Subjects:
Diabetic wound healing
Matrix metalloproteinase-9 (MMP-9)
Thermosensitive hydrogel
siRNA delivery
Online Access:https://doi.org/10.1186/s12951-021-00869-6

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