Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection

Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection

Plasmodium species produce an ortholog of the cytokine macrophage migration inhibitory factor, PMIF, which modulates the host inflammatory response to malaria. Here, the authors show that inhibition of PMIF may have translational benefits for managing malaria infections.

Bibliographic Details
Main Authors: Alvaro Baeza Garcia, Edwin Siu, Tiffany Sun, Valerie Exler, Luis Brito, Armin Hekele, Gib Otten, Kevin Augustijn, Chris J. Janse, Jeffrey B. Ulmer, Jürgen Bernhagen, Erol Fikrig, Andrew Geall, Richard Bucala
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05041-7

Internet

https://doi.org/10.1038/s41467-018-05041-7

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