Ras-Mediated Suppression of TGFβRII Expression in Intestinal Epithelial Cells Involves Raf-Independent Signaling

Ras-Mediated Suppression of TGFβRII Expression in Intestinal Epithelial Cells Involves Raf-Independent Signaling

Ras-transformed intestinal epithelial cells are resistant to the growth inhibitory actions of TGFβ and have a marked decrease in expression of the TGFβ type II receptor (TGFβRII). Rat intestinal epithelial cells (RIE) were stably transfected with activated Ras, Sos and Raf constructs and tested for...

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Bibliographic Details
Main Authors: Nada M. Bulus, Hong-Miao Sheng, Nywanna Sizemore, Sean M. Oldham, Joey V. Barnett, Robert J. Coffey, Daniel R. Beauchamp, John A. Barnard
Format: Article
Language:English
Published: Elsevier 2000-07-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Ras
colorectal carcinoma
TGFβ
Raf
intestinal epithelium
TGFβRII
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558600800081

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