Peripheral Inflammatory Hyperalgesia Depends on P2X7 Receptors in Satellite Glial Cells

Peripheral Inflammatory Hyperalgesia Depends on P2X7 Receptors in Satellite Glial Cells

Peripheral inflammatory hyperalgesia depends on the sensitization of primary nociceptive neurons. Inflammation drives molecular alterations not only locally but also in the dorsal root ganglion (DRG) where interleukin-1 beta (IL-1β) and purinoceptors are upregulated. Activation of the P2X7 purinocep...

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Bibliographic Details
Main Authors: Amanda Ferreira Neves, Felipe Hertzing Farias, Silviane Fernandes de Magalhães, Dionéia Araldi, Marco Pagliusi, Claudia Herrera Tambeli, Cesar Renato Sartori, Celina Monteiro da Cruz Lotufo, Carlos Amílcar Parada
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Physiology
Subjects:
satellite glial cells
P2X7 receptors
interleukin-1beta
dorsal root ganglion
inflammatory hyperalgesia
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00473/full

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https://www.frontiersin.org/article/10.3389/fphys.2020.00473/full

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