Correlation of BI-RADS grading with cancer cell proliferation and invasion

• Main Authors: Guang-Rong Sun, Xiao-Bo Zhao, Min Yang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-02-01
• Series: Journal of Hainan Medical University
• Subjects: Breast cancer; BI-RADS grading; Proliferation gene; Invasion gene
• Online Access: http://www.hnykdxxb.com/PDF/201802/34.pdf

Objective: To investigate the correlation of BI-RADS grading with cancer cell proliferation and invasion. Methods: A total of 138 patients who were diagnosed with breast cancer in our hospital between August 2015 and October 2017 were divided into 2 cases at stage Ⅲ, 51 cases at stage Ⅳ and 85 cases at stage Ⅴ after the BI-RADS grading was reviewed. Differences in the expression of proliferation-related genes and invasion-related genes were compared among the three groups of patients. Results: Expressions of pro-proliferation genes MTA2, mTOR, PKM2, Notch1 and FSCN1 mRNA in lesion tissue of patients at stage Ⅴ and Ⅳ were higher than those of patients at stage Ⅲ whereas expressions of anti-proliferation genes BRCA1 and PTEN mRNA were lower than those of patients at stage Ⅲ; expressions of pro-invasion genes Gab2 and NUAK1 mRNA were higher than those of patients at stage Ⅲ whereas expressions of anti-invasion genes EBP50, EDN3, FBXW7 and NDRG1 mRNA were lower than those of patients at stage Ⅲ. With the increase of BI-RADS grades, the expression levels of proproliferation genes and pro-invasion genes further increased while the expression levels of antiproliferation and anti-invasion genes further decreased in the lesion tissue. Conclusions: BIRADS grading of patients with breast cancer is positively correlated with the proliferation and invasion activity of cancer cells.