EFFECTS OF PSYCHOPHYSIOLOGICAL NEUROTHERAPY IN REGULATION IMMUNE RESPONSE COMBINED WITH STANDARD ANTITUBERCULOSIS DRUG THERAPY IN ACUTE PULMONARY TUBERCULOSIS

• Main Authors: O. V. Kolesnikova, T. I. Petrenko, T. A. Kolpakova, V. A. Trufakin
• Format: Article
• Language: Russian
• Published: SPb RAACI 2019-01-01
• Series: Medicinskaâ Immunologiâ
• Subjects: pulmonary tuberculosis; antistress therapy; immune system; phagocytosis; nk cells; cd16+; lung destruction foci
• Online Access: https://www.mimmun.ru/mimmun/article/view/1706
• ISSN: 1563-0625; 2313-741X

The aim of this study was to assess optimizing effects of antistress neurotechnologies on the clinical course of acute pulmonary tuberculosis. The study was performed in three steps: upon admission before treatment, followed by repeated examination at 2 and 4 months. The patients before study were divided into the two groups: (1) 33 patients received standard antituberculosis drug therapy (SDT) and (2) 35 cases after standard antituberculosis drug therapy accompanied by neurothechnological anti-stress therapy (NAT). Patients from the NAT group received a regular audio-visual-vibrotactile stimulation as additional therapy (2 to 3 30-min sessions per week during 4 months). By the time of hospitalization, the groups did not differ in their general immune state. The percentages of CD3+ , CD4+ , CD8+ , CD16+ , CD19+ as well as indexes of phagocyte activity showed some changes after 2 and 4 months of therapy. The patients from both groups before treatment exhibited lymphocytosis, decreased phagocyte activity, when compared to healthy individuals. By the end of therapy (4 months), the patients from the NAT group showed increased phagocytosis by monocytes (p < 0.01) and granulocytes (p < 0.05) which approached values of healthy control. The study demonstrated also that efficiency of combined therapy was higher in the NAT vs. SDT group: closure of lung destruction cavities was observed in 90.5% of patients from the NAT group vs 45% of patients from the STD group. The results present evidence for combined implementation of neurothechnological anti-stress therapies as a supplementary method for the standard specific drug therapy in primary infiltrative lung tuberculosis.