SREBP1-Induced Glutamine Synthetase Triggers a Feedforward Loop to Upregulate SREBP1 through Sp1 O-GlcNAcylation and Augments Lipid Droplet Formation in Cancer Cells

SREBP1-Induced Glutamine Synthetase Triggers a Feedforward Loop to Upregulate SREBP1 through Sp1 O-GlcNAcylation and Augments Lipid Droplet Formation in Cancer Cells

Glutamine and lipids are two important components of proliferating cancer cells. Studies have demonstrated that glutamine synthetase (GS) boosts glutamine-dependent anabolic processes for nucleotide and protein synthesis, but the role of GS in regulating lipogenesis remains unclear. This study ident...

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Bibliographic Details
Main Authors: Jin-Wei Jhu, Jia-Bao Yan, Zou-Han Lin, Shih-Chieh Lin, I-Chen Peng
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
sterol regulatory element-binding protein 1
glutamine synthetase
O-GlcNAcylation
lipid droplet
cancer
Online Access:https://www.mdpi.com/1422-0067/22/18/9814

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