Co-Treatment With Verapamil and Curcumin Attenuates the Behavioral Alterations Observed in Williams–Beuren Syndrome Mice by Regulation of MAPK Pathway and Microglia Overexpression

Co-Treatment With Verapamil and Curcumin Attenuates the Behavioral Alterations Observed in Williams–Beuren Syndrome Mice by Regulation of MAPK Pathway and Microglia Overexpression

Williams–Beuren syndrome (WBS) is a rare neurodevelopmental disorder characterized by a distinctive cognitive phenotype for which there are currently no effective treatments. We investigated the progression of behavioral deficits present in WBS complete deletion (CD) mice, after chronic treatment wi...

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Bibliographic Details
Main Authors: Paula Ortiz-Romero, Alejandro González-Simón, Gustavo Egea, Luis A. Pérez-Jurado, Victoria Campuzano
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
Williams–Beuren syndrome
curcumin
verapamil
mice
activated glia
behavior
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.670785/full

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