Role of Tyrosine Phosphorylation in The Antioxidant Effects of The P75 Neurotrophin Receptor

The p75 neurotrophin receptor (p75NTR) is an α-and γ-secretase substrate expressed preferentially in the cholinergic neurons of the nucleus basalis of Meynert, the hippocampus, and the cerebellum of the adult brain. Mutations of the γ-secretase, presenilin, have been implicated in familial Alzheimer...

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Bibliographic Details
Main Authors: Tong Zhang, Zhiping Mi, Nina F. Schor
Format: Article
Language:English
Published: Hindawi Limited 2009-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.4161/oxim.2.4.9745