The Evolution of the Secreted Regulatory Protein Progranulin.

The Evolution of the Secreted Regulatory Protein Progranulin.

Progranulin is a secreted growth factor that is active in tumorigenesis, wound repair, and inflammation. Haploinsufficiency of the human progranulin gene, GRN, causes frontotemporal dementia. Progranulins are composed of chains of cysteine-rich granulin modules. Modules may be released from progranu...

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Bibliographic Details
Main Authors: Roger G E Palfree, Hugh P J Bennett, Andrew Bateman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4527844?pdf=render

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