Tranexamic acid in diffuse alveolar hemorrhage (case report)

• Main Authors: Owlia MB, Bayatian A, Halvani A
• Format: Article
• Language: fas
• Published: Tehran University of Medical Sciences 2007-05-01
• Series: Tehran University Medical Journal
• Subjects: Diffuse alveolar hemorrhage (DAH); Wagener’s granulomatosis
• Online Access: http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/3267.pdf&manuscript_id=3267

Background: Wagener's granulomatosis (WG) is a systemic necrotizing vasculitis characterized by upper and lower respiratory tract involvement and glomerulonephritis in most instances. Case Report: We report a 36 years old man with DAH secondary to WG, as the presenting feature. He successfully treated with standard immune suppressive agents including pulse methylprednisolone and cyclophospha-mide, along with tranexamic acid as adjunctive therapy for control of active bleeding. Laboratory results showed mild to moderate anemia, increased serum lactate dehydrogenase and very high c-ANCA titer. Chest radiograph showed bilateral alveolar infilterates. Conclusion: Diffuse Alveolar hemorrhage (DAH) is a dread complication of Wagener’s granulomatosis. Control of acute phase of hemorrhage with tranexamic acid can improve out come of patients.