Impact of Vitamin D Supplementation on Influenza Vaccine Response and Immune Functions in Deficient Elderly Persons: A Randomized Placebo-Controlled Trial

Impact of Vitamin D Supplementation on Influenza Vaccine Response and Immune Functions in Deficient Elderly Persons: A Randomized Placebo-Controlled Trial

Background: Immunosenescence contributes to reduced vaccine response in elderly persons, and is worsened by deficiencies in nutrients such as Vitamin (Vit-D). The immune system is a well-known target of Vit-D, which can both potentiate the innate immune response and inhibit the adaptive system, and...

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Bibliographic Details
Main Authors: Nicolas Goncalves-Mendes, Jérémie Talvas, Christian Dualé, Aline Guttmann, Violaine Corbin, Geoffroy Marceau, Vincent Sapin, Patrick Brachet, Bertrand Evrard, Henri Laurichesse, Marie-Paule Vasson
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
vitamin-D deficiency
influenza vaccination
aging
cathelicidin
cytokine
leukocyte phenotyping
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00065/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00065/full

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