Iron Chelator Induces Apoptosis in Osteosarcoma Cells by Disrupting Intracellular Iron Homeostasis and Activating the MAPK Pathway

Iron Chelator Induces Apoptosis in Osteosarcoma Cells by Disrupting Intracellular Iron Homeostasis and Activating the MAPK Pathway

Osteosarcoma is a common malignant bone tumor in clinical orthopedics. Iron chelators have inhibitory effects on many cancers, but their effects and mechanisms in osteosarcoma are still uncertain. Our in vitro results show that deferoxamine (DFO) and deferasirox (DFX), two iron chelators, significan...

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Bibliographic Details
Main Authors: Yanru Xue, Gejing Zhang, Shoujie Zhou, Shenghang Wang, Huanhuan Lv, Liangfu Zhou, Peng Shang
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
iron chelators
iron metabolism
ROS
osteosarcoma
MAPK signaling pathway
apoptosis
Online Access:https://www.mdpi.com/1422-0067/22/13/7168

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