Effect of Propranolol in Human Body Using Gold Nanoparticles by Spectrofluorometric Method

• Main Authors: Ali Akbar Shadbahr, Farzaneh Marahel
• Format: Article
• Language: fas
• Published: Alborz University of Medical Sciencs 2018-12-01
• Series: Bihdād
• Subjects: Gold nanoparticles; Propranolol drug; Spectrofluorometric device; Gold salt
• Online Access: http://aums.abzums.ac.ir/browse.php?a_code=A-10-1-230&slc_lang=en&sid=1

In this method, gold nanoparticles have been synthesized by reducing the gold salt and the Spectrofluorometric spectrum is taken from it. Determination of  propranolol is widely used in the treatment of blood pressure and irregular heart beat .The effects of different parameters such as pH; volume of buffer; volume of gold nanoparticles and remaining time are investigated. The results showed that the optimal pH value of 6, 2.5 milliliters as the optimum buffer volume, the optimal volume of gold nanoparticles was 3 milliliters and 6 minutes as the optimum remaining time was determined for specimens and following it the response of the nanoparticles to the drug has been plotted. After determining the calibration curve, it was determined that a very wide linear range of drug can be investigated using this method. The method has been found to have appropriate figure merits. At the end of the study, golden Nano sensor was used in real samples such as blood and urine to measure propranolol and obtained satisfactory results.