Differential Requirements for Src-Family Kinases in SYK or ZAP70-Mediated SLP-76 Phosphorylation in Lymphocytes

Differential Requirements for Src-Family Kinases in SYK or ZAP70-Mediated SLP-76 Phosphorylation in Lymphocytes

In a synthetic biology approach using Schneider (S2) cells, we show that SLP-76 is directly phosphorylated at tyrosines Y113 and Y128 by SYK in the presence of ITAM-containing adapters such as CD3ζ, DAP12, or FcεRγ. This phosphorylation was dependent on at least one functional ITAM and a functional...

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Bibliographic Details
Main Authors: Frank Fasbender, Maren Claus, Sabine Wingert, Mina Sandusky, Carsten Watzl
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Immunology
Subjects:
natural killer cells
synthetic biology
signal transduction
SLP-76
SYK
Src-family kinases
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00789/full

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