Intra-Cellular Calcium Signaling Pathways (PKC, RAS/RAF/MAPK, PI3K) in Lamina Cribrosa Cells in Glaucoma

Intra-Cellular Calcium Signaling Pathways (PKC, RAS/RAF/MAPK, PI3K) in Lamina Cribrosa Cells in Glaucoma

The lamina cribrosa (LC) is a key site of fibrotic damage in glaucomatous optic neuropathy and the precise mechanisms of LC change remain unclear. Elevated Ca<sup>2+</sup> is a major driver of fibrosis, and therefore intracellular Ca<sup>2+</sup> signaling pathways are releva...

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Bibliographic Details
Main Authors: Mustapha Irnaten, Aisling Duff, Abbot Clark, Colm O’Brien
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Journal of Clinical Medicine
Subjects:
glaucoma
lamina cribrosa
fibrosis
calcium
PKCα
<i>p</i>38-MAPK
Online Access:https://www.mdpi.com/2077-0383/10/1/62

Internet

https://www.mdpi.com/2077-0383/10/1/62

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