Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles

Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease affecting the upper and lower motor neurons in the motor cortex and spinal cord. Abnormal accumulation of mutant superoxide dismutase I (SOD1) in motor neurons is a pathological hallmark of some forms of the disease. We have sh...

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Bibliographic Details
Main Authors: Liyu Chen, Clare Watson, Marco Morsch, Nicholas J. Cole, Roger S. Chung, Darren N. Saunders, Justin J. Yerbury, Kara L. Vine
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Neuroscience
Subjects:
amyotrophic lateral sclerosis
motor neurone disease
drug delivery
calcium phosphate nanoparticle
antisense oligonucleotide
SOD1
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00476/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2017.00476/full

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