The mechanism of BMI1 in regulating cancer stemness maintenance, metastasis, chemo- and radiation resistance

• Main Authors: Xiaoshan Xu, Zhen Wang, Nan Liu, Pengxing Zhang, Hui Liu, Jing Qi, Yanyang Tu
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2018-01-01
• Series: Cancer Translational Medicine
• Subjects: BMI1; chemo and radiation resistance; metastasis; tumor stemness maintenance
• Online Access: http://www.cancertm.com/article.asp?issn=2395-3977;year=2018;volume=4;issue=2;spage=59;epage=63;aulast=Xu
• ISSN: 2395-3977; 2395-3012

BMI1 is involved in the occurrence and development of many types of cancer through a variety of signaling pathways. BMI1, which is overexpressed in cancer, is often associated with chemo- and radiation resistance and poor prognosis in cancer patients. This article reviews the current understanding of the mechanism of BMI1 in maintaining tumor stemness, promoting metastasis, and inducing chemo- and radiation resistance, aiming at providing updated information supportive of targeting BMI1 in cancer treatment.