Validation of a quantitative systems pharmacology model of calcium homeostasis using elagolix Phase 3 clinical trial data in women with endometriosis

Abstract Elagolix is a novel, oral gonadotropin‐releasing hormone receptor antagonist indicated for the management of moderate to severe pain associated with endometriosis and heavy menstrual bleeding associated with uterine fibroids. Consistent with its mechanism of action, elagolix exhibited dose‐...

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Bibliographic Details
Main Authors: Sven Stodtmann, Ahmed Nader, Akshanth R. Polepally, Ahmed A. Suleiman, Insa Winzenborg, Peter Noertersheuser, Juki Ng, Nael M. Mostafa, Mohamad Shebley
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.13040