Plasmodium falciparum cGMP-Dependent Protein Kinase – A Novel Chemotherapeutic Target

Plasmodium falciparum cGMP-Dependent Protein Kinase – A Novel Chemotherapeutic Target

The primary effector of cGMP signaling in Plasmodium is the cGMP-dependent protein kinase (PKG). Work in human-infective Plasmodium falciparum and rodent-infective Plasmodium berghei has provided biological validation of P. falciparum PKG (PfPKG) as a drug target for treating and/or protecting again...

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Bibliographic Details
Main Authors:	David Rotella, John Siekierka, Purnima Bhanot
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-02-01
Series:	Frontiers in Microbiology
Subjects:	Plasmodium malaria cGMP signaling second messenger kinase
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2020.610408/full

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