Relationship Between Muscle Mass and Insulin Resistance in Cirrhotic Patients with Hepatitis B

• Main Authors: Eyüp Sami Akbaş, Betül Ayaz, Beyza Selin Haksever, Sema Basat
• Format: Article
• Language: English
• Published: KARE Publishing 2019-07-01
• Series: Southern Clinics of Istanbul Eurasia
• Subjects: cirrhosis; hepatitis b; insulin resistance; muscle mass.
• Online Access: https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-03164

INTRODUCTION[|]Hepatitis B virus (HBV) affects over 400 million people in the world and is a major threat despite all measures taken for its prevention. It is one of the most important causes of liver cirrhosis. Liver cirrhosis causes malnutrition as a result of decreased oral intake, both because of the disease itself and multiple other reasons. Studies showed an inverse correlation between muscle mass and insulin resistance. We aimed to evaluate the relationship between insulin resistance, muscle mass, and muscle strength in patients with HBV-related cirrhosis. [¤]METHODS[|]We included 65 patients with HBV-related cirrhosis in Child-Pugh class A and B groups and 65 healthy control individuals in this monocentric study. Muscle mass indices were calculated with bioimpedance analysis for both groups to determine muscle strength and muscle mass. Handgrip strength, arm, and calf circumferences were measured. In both groups, HOMA-IR values were calculated to determine insulin resistance. Correlations of fasting glucose, fasting insulin, HbA1C, LDL, HDL, triglyceride, and cholesterol levels with calf and waist circumference measurements were detected. The relationship between muscle mass and insulin resistance, laboratory results, and waist and calf circumference was evaluated. [¤]RESULTS[|]The mean value of muscle mass index was 10.98+-11.40 kg/m2 in cirrhotic patients and 9.88+-1.12 kg/m2 in healthy control individuals. HOMA-IR values were detected as 3.47+-3.80 in the study group and 1.83+-1.20 in the control group. The correlation coefficient between muscle mass and insulin resistance was statistically insignificant, especially in the study group. [¤]DISCUSSION AND CONCLUSION[|]In our study, there was no relationship between muscle mass and insulin resistance in cirrhotic patients with hepatitis B.[¤]