Functional characterization of the cytochrome P450 monooxygenase CYP71AU87 indicates a role in marrubiin biosynthesis in the medicinal plant Marrubium vulgare

Functional characterization of the cytochrome P450 monooxygenase CYP71AU87 indicates a role in marrubiin biosynthesis in the medicinal plant Marrubium vulgare

Abstract Background Horehound (Marrubium vulgare) is a medicinal plant whose signature bioactive compounds, marrubiin and related furanoid diterpenoid lactones, have potential applications for the treatment of cardiovascular diseases and type II diabetes. Lack of scalable plant cultivation and the c...

Full description

Bibliographic Details
Main Authors: Prema S. Karunanithi, Puja Dhanota, J. Bennett Addison, Shen Tong, Oliver Fiehn, Philipp Zerbe
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Plant Biology
Subjects:
Diterpene synthase
Cytochrome P450 monooxygenase
Diterpenoid biosynthesis
Marrubiin
Plant natural products
Marrubium vulgare
Online Access:http://link.springer.com/article/10.1186/s12870-019-1702-5

Internet

http://link.springer.com/article/10.1186/s12870-019-1702-5

Similar Items