Severe childhood and adulthood stress associates with neocortical layer-specific reductions of mature spines in psychiatric disorders

Severe childhood and adulthood stress associates with neocortical layer-specific reductions of mature spines in psychiatric disorders

Severe stress exposure causes the loss of dendritic spines on cortical pyramidal neurons and induces psychiatric-like symptoms in rodent models. These effects are strongest following early-life stress and are most persistent on apical dendrites. However, the long-term impacts and temporal effects of...

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Bibliographic Details
Main Authors: Dominic Kaul, Caine C. Smith, Julia Stevens, Anna S. Fröhlich, Elisabeth B. Binder, Naguib Mechawar, Sibylle G. Schwab, Natalie Matosin
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Neurobiology of Stress
Subjects:
Stress
Psychiatry
Dendritic spines
Cytoarchitecture
Cortex
Early-life adversity
Online Access:http://www.sciencedirect.com/science/article/pii/S2352289520300606

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http://www.sciencedirect.com/science/article/pii/S2352289520300606

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