THE SAFETY ASSESSMENT OF MEDICINAL PLANTS

• Main Authors: E. V. Shikh, V. M. Bulayev, O. A. Demidova
• Format: Article
• Language: Russian
• Published: Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian Federation 2018-02-01
• Series: Безопасность и риск фармакотерапии
• Subjects: безопасность лекарственных растений; токсичные тяжелые металлы; пестициды; эндогенные токсичные вещества лекарственных растений; предельно допустимые концентрации токсичных компонентов; повышение требований к безопасности лекарственных растений; нормативная документация на лекарственные растения; the safety of medicinal plants; toxic heavy metals; pesticides; endogenous toxic substances of medicinal plants; maximum allowable concentrations of toxic components; increasing security requirements of medicinal plants; normative documentation on medicinal plants
• Online Access: https://www.risksafety.ru/jour/article/view/12

The problems of safety evaluation of medicinal plants formulations in the Russian Federation, Europe and USA are presented. Safety issues of medicinal plants, as well as the adverse reactions of some herbal medicines are discussed. The main groups of exogenous (toxic metals, pesticides) and endogenous toxic substances of medicinal plants are represented. The maximum allowable concentrations of endogenous toxic substances (pyrrolizidine alkaloids, glycolic acid, azaron and other) most often defined in medicinal plants are given. The authors substantiate the necessity of tightening of the requirements for normative documents, which ensure the safety of medicinal plants.