The taming of PARP1 and its impact on NAD+ metabolism
Background: Poly-ADP-ribose polymerases (PARPs) are key mediators of cellular stress response. They are intimately linked to cellular metabolism through the consumption of NAD+. PARP1/ARTD1 in the nucleus is the major NAD+ consuming activity and plays a key role in maintaining genomic integrity. Sco...
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2020-08-01
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| Series: | Molecular Metabolism |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212877820300223 |
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doaj-bda960c0b4454daf929ae60dac2a0f1b2020-11-25T03:59:10ZengElsevierMolecular Metabolism2212-87782020-08-0138100950The taming of PARP1 and its impact on NAD+ metabolismSarah Hurtado-Bagès0Gunnar Knobloch1Andreas G. Ladurner2Marcus Buschbeck3Josep Carreras Leukemia Research Institute, Campus ICO-Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916, Badalona, Spain; Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, SpainBiomedical Center Munich, Physiological Chemistry, Ludwig-Maximilians-Universität München, 82152, Planegg-Martinsried, GermanyBiomedical Center Munich, Physiological Chemistry, Ludwig-Maximilians-Universität München, 82152, Planegg-Martinsried, Germany; Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität München, 81377, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-Universität München, 81377, Munich, Germany; Corresponding author. Biomedical Center Munich, Physiological Chemistry, Ludwig-Maximilians-Universität München, 82152, Planegg-Martinsried, Germany.Josep Carreras Leukemia Research Institute, Campus ICO-Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916, Badalona, Spain; Program for Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute (PMPPC-IGTP), 08916, Badalona, Spain; Corresponding author. Josep Carreras Leukemia Research Institute, Campus ICO-Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916, Badalona, Spain.Background: Poly-ADP-ribose polymerases (PARPs) are key mediators of cellular stress response. They are intimately linked to cellular metabolism through the consumption of NAD+. PARP1/ARTD1 in the nucleus is the major NAD+ consuming activity and plays a key role in maintaining genomic integrity. Scope of review: In this review, we discuss how different organelles are linked through NAD+ metabolism and how PARP1 activation in the nucleus can impact the function of distant organelles. We discuss how differentiated cells tame PARP1 function by upregulating an endogenous inhibitor, the histone variant macroH2A1.1. Major conclusions: The presence of macroH2A1.1, particularly in differentiated cells, raises the threshold for the activation of PARP1 with consequences for DNA repair, gene transcription, and NAD+ homeostasis.http://www.sciencedirect.com/science/article/pii/S2212877820300223PARP1NAD+EpigeneticsMacroH2AMetabolismHomeostasis |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sarah Hurtado-Bagès Gunnar Knobloch Andreas G. Ladurner Marcus Buschbeck |
| spellingShingle |
Sarah Hurtado-Bagès Gunnar Knobloch Andreas G. Ladurner Marcus Buschbeck The taming of PARP1 and its impact on NAD+ metabolism Molecular Metabolism PARP1 NAD+ Epigenetics MacroH2A Metabolism Homeostasis |
| author_facet |
Sarah Hurtado-Bagès Gunnar Knobloch Andreas G. Ladurner Marcus Buschbeck |
| author_sort |
Sarah Hurtado-Bagès |
| title |
The taming of PARP1 and its impact on NAD+ metabolism |
| title_short |
The taming of PARP1 and its impact on NAD+ metabolism |
| title_full |
The taming of PARP1 and its impact on NAD+ metabolism |
| title_fullStr |
The taming of PARP1 and its impact on NAD+ metabolism |
| title_full_unstemmed |
The taming of PARP1 and its impact on NAD+ metabolism |
| title_sort |
taming of parp1 and its impact on nad+ metabolism |
| publisher |
Elsevier |
| series |
Molecular Metabolism |
| issn |
2212-8778 |
| publishDate |
2020-08-01 |
| description |
Background: Poly-ADP-ribose polymerases (PARPs) are key mediators of cellular stress response. They are intimately linked to cellular metabolism through the consumption of NAD+. PARP1/ARTD1 in the nucleus is the major NAD+ consuming activity and plays a key role in maintaining genomic integrity. Scope of review: In this review, we discuss how different organelles are linked through NAD+ metabolism and how PARP1 activation in the nucleus can impact the function of distant organelles. We discuss how differentiated cells tame PARP1 function by upregulating an endogenous inhibitor, the histone variant macroH2A1.1. Major conclusions: The presence of macroH2A1.1, particularly in differentiated cells, raises the threshold for the activation of PARP1 with consequences for DNA repair, gene transcription, and NAD+ homeostasis. |
| topic |
PARP1 NAD+ Epigenetics MacroH2A Metabolism Homeostasis |
| url |
http://www.sciencedirect.com/science/article/pii/S2212877820300223 |
| work_keys_str_mv |
AT sarahhurtadobages thetamingofparp1anditsimpactonnadmetabolism AT gunnarknobloch thetamingofparp1anditsimpactonnadmetabolism AT andreasgladurner thetamingofparp1anditsimpactonnadmetabolism AT marcusbuschbeck thetamingofparp1anditsimpactonnadmetabolism AT sarahhurtadobages tamingofparp1anditsimpactonnadmetabolism AT gunnarknobloch tamingofparp1anditsimpactonnadmetabolism AT andreasgladurner tamingofparp1anditsimpactonnadmetabolism AT marcusbuschbeck tamingofparp1anditsimpactonnadmetabolism |
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