Evaluation of HTLV-1 in Human Subgingival Plaque of Seropositive Patients

• Main Authors: N. Sargolzaee, HR. Arab, A. Moeintaghavi, M. Radvar
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2008-09-01
• Series: Frontiers in Dentistry
• Subjects: Human T-lymphotropic virus 1; Dental Plaque; Polymerase Chain Reaction
• Online Access: https://jdt.tums.ac.ir/index.php/jdt/article/view/157

Objective: The aim of this study was to investigate the existence of human T-lymphotropic virus type 1 (HTLV-1) in subgingival plaque of HTLV-1 seropositive pa-tients. Materials and Methods: A total of 18 patients including 13 females and fivemales, with a mean age of 37 years participated in this descriptive study. Half of them were HTLV-1 carriers and the others were in HTLV-1 associated myelopathy tropical spastic paraparesia (HAM/TSP) stage.Subgingival dental plaque samples were taken using sterile paper points and examined to detect HTLV-1 using polymerase chain reaction (PCR). Results: None of the carrier stage patients revealed HTLV-1 virus, while only one patient in the HAM/TSP group was found with the virus. Conclusion: This study showed that the existence of HTLV-1 virus in subgingival plaque of patients suffering from HTLV-1 in carrier and HAM/TSP stages with healthy periodon-tium is rare. Studies with larger samples are recommended.