T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication.

T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication.

HIV infects key cell types of the immune system, most notably macrophages and CD4+ T cells. Whereas macrophages represent an important viral reservoir, activated CD4+ T cells are the most permissive cell types supporting high levels of viral replication. In recent years, it has been appreciated that...

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Bibliographic Details
Main Authors: Randi K Berg, Stine H Rahbek, Emil Kofod-Olsen, Christian K Holm, Jesper Melchjorsen, David G Jensen, Anne Louise Hansen, Louise B Jørgensen, Lars Ostergaard, Martin Tolstrup, Carsten S Larsen, Søren R Paludan, Martin R Jakobsen, Trine H Mogensen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3880311?pdf=render

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http://europepmc.org/articles/PMC3880311?pdf=render

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