Assessment of the genotoxic/clastogenic potential of coumarin derivative 6,7-dihydroxycoumarin (aesculetin) in multiple mouse organs

Assessment of the genotoxic/clastogenic potential of coumarin derivative 6,7-dihydroxycoumarin (aesculetin) in multiple mouse organs

6,7-Dihydroxycoumarin (6,7-HC) (aesculetin) is a natural and synthetic coumarin derivative of great interest for use by humans due to their potent antioxidant properties. Considering that there are no reports that assess the in vivo genetic toxicity of 6,7-HC, the aim of the present study was to inv...

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Bibliographic Details
Main Authors: Eduardo de Souza Marques, Daiane Bernardoni Salles, Edson Luis Maistro
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Toxicology Reports
Subjects:
Coumarin derivative
Aesculetin
6,7-Dihydroxycoumarin
Antigenotoxic effects
Comet assay
Micronucleus test
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750015000074

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