Novel Antibodies Targeting MUC1-C Showed Anti-Metastasis and Growth-Inhibitory Effects on Human Breast Cancer Cells

Novel Antibodies Targeting MUC1-C Showed Anti-Metastasis and Growth-Inhibitory Effects on Human Breast Cancer Cells

Mucin1 (MUC1) is aberrantly glycosylated and overexpressed in various cancers, and it plays a crucial role in cancerogenesis. MUC1 is a type I membranous protein composed of α and β subunits. MUC1-α can be cleaved in cancers, exposing MUC1-β (MUC1-C). MUC1-C is involved with multiple cancer cellular...

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Bibliographic Details
Main Authors: Min Jung Kim, Jong Rip Choi, Nara Tae, Tae Min Wi, Kristine M. Kim, Dae Hee Kim, Eung Suk Lee
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
MUC1-C
Mucin1-C terminal domain
Metastasis
survival
TNBC
Online Access:https://www.mdpi.com/1422-0067/21/9/3258

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