MCL-1, BCL-XL and MITF Are Diversely Employed in Adaptive Response of Melanoma Cells to Changes in Microenvironment.
Melanoma cells can switch their phenotypes in response to microenvironmental insults. Heterogeneous melanoma populations characterized by long-term growth and a high self-renewal capacity can be obtained in vitro in EGF(+)bFGF(+) medium whilst invasive potential of melanoma cells is increased in ser...
Main Authors: | Mariusz L Hartman, Beata Talar, Anna Gajos-Michniewicz, Malgorzata Czyz |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
|
Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0128796 |
Similar Items
-
Gene expression profiling identifies microphthalmia-associated transcription factor (MITF) and Dickkopf-1 (DKK1) as regulators of microenvironment-driven alterations in melanoma phenotype.
by: Mariusz L Hartman, et al.
Published: (2014-01-01) -
Pentoxifylline Inhibits WNT Signalling in β-Cateninhigh Patient-Derived Melanoma Cell Populations.
by: Beata Talar, et al.
Published: (2016-01-01) -
Glutathione and Bcl-2 targeting facilitates elimination by chemoradiotherapy of human A375 melanoma xenografts overexpressing <it>bcl-xl</it>, <it>bcl-2</it>, and <it>mcl-1</it>
by: Mena Salvador, et al.
Published: (2012-01-01) -
WNT Signaling in Melanoma
by: Anna Gajos-Michniewicz, et al.
Published: (2020-07-01) -
Inhibition of Antiapoptotic BCL-XL, BCL-2, and MCL-1 Proteins by Small Molecule Mimetics
by: D.S. Dalafave, et al.
Published: (2010-08-01)