Relapse Following Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia Apparently Due to Somatic Cell Evolution via Epigenetic Variation and Immune Selection

Relapse Following Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia Apparently Due to Somatic Cell Evolution via Epigenetic Variation and Immune Selection

In this brief commentary, I discuss a recently published study that documents the role of immune escape in relapse of acute myeloid leukemia (AML) after hematopoietic cell transplantation (HCT). Of particular interest, the mechanism identified by the authors for the ability of the malignant cells to...

Full description

Bibliographic Details
Main Author: Neil S. Greenspan
Format: Article
Language:English
Published: Case Western Reserve University 2019-02-01
Series:Pathogens and Immunity
Subjects:
acute myeloid leukemia (AML)
malignancy
blasts
allogeneic hematopoietic cell transplantation (HCT)
chemotherapy
relapse
T cells
cytotoxicity
whole exome sequencing
mutation
epigenetic
HLA class II
HLA class I
interferon gamma
clone
subclone
Online Access:https://paijournal.com/index.php/paijournal/article/view/285

Internet

https://paijournal.com/index.php/paijournal/article/view/285

Similar Items