Development of Novel <sup>111</sup>-In-Labelled DOTA Urotensin II Analogues for Targeting the UT Receptor Overexpressed in Solid Tumours

Development of Novel <sup>111</sup>-In-Labelled DOTA Urotensin II Analogues for Targeting the UT Receptor Overexpressed in Solid Tumours

Overexpression of G protein-coupled receptors (GPCRs) in tumours is widely used to develop GPCR-targeting radioligands for solid tumour imaging in the context of diagnosis and even treatment. The human vasoactive neuropeptide urotensin II (hUII), which shares structural analogies with somatostatin,...

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Bibliographic Details
Main Authors: Benjamin Poret, Laurence Desrues, Marc-André Bonin, Martin Pedard, Martine Dubois, Richard Leduc, Romain Modzelewski, Pierre Decazes, Fabrice Morin, Pierre Vera, Hélène Castel, Pierre Bohn, Pierrick Gandolfo
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Biomolecules
Subjects:
<sup>111</sup>indium-dota-peptide analogues
urotensin ii
ut receptor
carcinoma
radiolabelling
Online Access:https://www.mdpi.com/2218-273X/10/3/471

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