Diosbulbin B-Induced Mitochondria-Dependent Apoptosis in L-02 Hepatocytes is Regulated by Reactive Oxygen Species-Mediated Autophagy

Diosbulbin B-Induced Mitochondria-Dependent Apoptosis in L-02 Hepatocytes is Regulated by Reactive Oxygen Species-Mediated Autophagy

Aim: Diosbulbin B (DB) is a major diterpenoid compound found in Dioscorea bulbifera L, a traditional medicinal herb in China. Clinical reports have confirmed that Dioscorea bulbifera L. can induce significant hepatotoxicity. In this study, we showed that DB can induce mitochondria-dependent apoptosi...

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Bibliographic Details
Main Authors: Jing Ye, Mei Xue, Yamin Liu, Sirui Zhu, Yu Li, Xiaoli Liu, Danhong Cai, Jia Rui, Liang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Pharmacology
Subjects:
diosbulbin B
autophagy
mitochondrial dysfunction
apoptosis
hepatocytes
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00676/full

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