Permeation of Polymethoxyflavones into the Mouse Brain and Their Effect on MK-801-Induced Locomotive Hyperactivity

Permeation of Polymethoxyflavones into the Mouse Brain and Their Effect on MK-801-Induced Locomotive Hyperactivity

Accumulating data have indicated that citrus polymethoxyflavones (PMFs) have the ability to affect brain function. In the present study, we showed that 3,5,6,7,8,3′,4′-heptamethoxy- flavone (HMF) given intraperitoneally to mice was immediately detected in the brain and that the permeability of the b...

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Bibliographic Details
Main Authors:	Satoshi Okuyama, Kohei Miyazaki, Rie Yamada, Yoshiaki Amakura, Morio Yoshimura, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukawa
Format:	Article
Language:	English
Published:	MDPI AG 2017-02-01
Series:	International Journal of Molecular Sciences
Subjects:	polymethoxyflavone heptamethoxyflavone nobiletin tangeretin natsudaidain blood-brain-barrier locomotive hyperactivity ERK1/2 MK-801
Online Access:	http://www.mdpi.com/1422-0067/18/3/489

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