Production of enantiopure (R)- or (S)-2-hydroxy-4-(methylthio)butanoic acid by multi-enzyme cascades

Production of enantiopure (R)- or (S)-2-hydroxy-4-(methylthio)butanoic acid by multi-enzyme cascades

Abstract (R)- or (S)-2-Hydroxy-4-(methylthio)butanoic acid (HMTBA) is used as a poultry nutritional supplement and to treat renal failure disease. Herein, we report an artificially designed biocatalytic cascade process, which uses l-methionine to synthesize (R)- or (S)-HMTBA. This biocatalysis casca...

Full description

Bibliographic Details
Main Authors: Can Zhang, Wei Song, Jia Liu, Xiulai Chen, Liming Liu
Format: Article
Language:English
Published: SpringerOpen 2019-02-01
Series:Bioresources and Bioprocessing
Subjects:
(R)- or (S)-2-Hydroxy-4-(methylthio)butanoic acid
Enzyme cascades
l-Amino acid deaminase
Lactate dehydrogenase
Modular assembly
Online Access:http://link.springer.com/article/10.1186/s40643-019-0244-x

Internet

http://link.springer.com/article/10.1186/s40643-019-0244-x

Similar Items