Relationship between circulating miR-132 and non-alcoholic fatty liver disease in a Chinese population

Abstract Background Non-invasive diagnostic markers are of great importance for early screening nonalcoholic fatty liver disease (NAFLD). MicroRNAs (miRNAs) play significant roles in many metabolic disease, including NAFLD. Therefore, this study focusd on a Chinese population to explore the possible...

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Main Authors:	Yicen Zong, Jing Yan, Li Jin, Bo Xu, Zhen He, Rong Zhang, Cheng Hu, Weiping Jia
Format:	Article
Language:	English
Published:	BMC 2020-05-01
Series:	Hereditas
Subjects:	NAFLD T2DM miR-132 TG ALT
Online Access:	http://link.springer.com/article/10.1186/s41065-020-00136-y

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spelling	doaj-bd3d092cfe8543cc9080c60d745014c52020-11-25T03:08:33ZengBMCHereditas1601-52232020-05-0115711810.1186/s41065-020-00136-yRelationship between circulating miR-132 and non-alcoholic fatty liver disease in a Chinese populationYicen Zong0Jing Yan1Li Jin2Bo Xu3Zhen He4Rong Zhang5Cheng Hu6Weiping Jia7Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalAbstract Background Non-invasive diagnostic markers are of great importance for early screening nonalcoholic fatty liver disease (NAFLD). MicroRNAs (miRNAs) play significant roles in many metabolic disease, including NAFLD. Therefore, this study focusd on a Chinese population to explore the possible correlation between circulating miR-132 and NAFLD. Results Serum miR-132 was positively associated with NAFLD in non-type 2 diabetes mellitus (T2DM) groups by logistic regression (OR = 3.082 [1.057, 8.988], P = 0.039) after adjusting age, sex, and body mass index (BMI). Additionally, in non-T2DM subgroup, after adjusting age, sex, bmi, serum miR-132 was significantly associated with ALT (β ± SE = 0.005 ± 0.002, P = 0.018), TG (β ± SE = 0.072 ± 0.029, P = 0.015), FPG (β ± SE = 0.123 ± 0.058, P = 0.036), γ-GT (β ± SE = 0.002 ± 0.001, P = 0.047), apoE (β ± SE = 0.038 ± 0.002, P = 0.017) . Conclusions Serum miR-132 was found to be associated with NAFLD risk in a Chinese cross-section study. This finding provides a prospective research direction for early screening and diagnosing NAFLD.http://link.springer.com/article/10.1186/s41065-020-00136-yNAFLDT2DMmiR-132TGALT
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yicen Zong Jing Yan Li Jin Bo Xu Zhen He Rong Zhang Cheng Hu Weiping Jia
spellingShingle	Yicen Zong Jing Yan Li Jin Bo Xu Zhen He Rong Zhang Cheng Hu Weiping Jia Relationship between circulating miR-132 and non-alcoholic fatty liver disease in a Chinese population Hereditas NAFLD T2DM miR-132 TG ALT
author_facet	Yicen Zong Jing Yan Li Jin Bo Xu Zhen He Rong Zhang Cheng Hu Weiping Jia
author_sort	Yicen Zong
title	Relationship between circulating miR-132 and non-alcoholic fatty liver disease in a Chinese population
title_short	Relationship between circulating miR-132 and non-alcoholic fatty liver disease in a Chinese population
title_full	Relationship between circulating miR-132 and non-alcoholic fatty liver disease in a Chinese population
title_fullStr	Relationship between circulating miR-132 and non-alcoholic fatty liver disease in a Chinese population
title_full_unstemmed	Relationship between circulating miR-132 and non-alcoholic fatty liver disease in a Chinese population
title_sort	relationship between circulating mir-132 and non-alcoholic fatty liver disease in a chinese population
publisher	BMC
series	Hereditas
issn	1601-5223
publishDate	2020-05-01
description	Abstract Background Non-invasive diagnostic markers are of great importance for early screening nonalcoholic fatty liver disease (NAFLD). MicroRNAs (miRNAs) play significant roles in many metabolic disease, including NAFLD. Therefore, this study focusd on a Chinese population to explore the possible correlation between circulating miR-132 and NAFLD. Results Serum miR-132 was positively associated with NAFLD in non-type 2 diabetes mellitus (T2DM) groups by logistic regression (OR = 3.082 [1.057, 8.988], P = 0.039) after adjusting age, sex, and body mass index (BMI). Additionally, in non-T2DM subgroup, after adjusting age, sex, bmi, serum miR-132 was significantly associated with ALT (β ± SE = 0.005 ± 0.002, P = 0.018), TG (β ± SE = 0.072 ± 0.029, P = 0.015), FPG (β ± SE = 0.123 ± 0.058, P = 0.036), γ-GT (β ± SE = 0.002 ± 0.001, P = 0.047), apoE (β ± SE = 0.038 ± 0.002, P = 0.017) . Conclusions Serum miR-132 was found to be associated with NAFLD risk in a Chinese cross-section study. This finding provides a prospective research direction for early screening and diagnosing NAFLD.
topic	NAFLD T2DM miR-132 TG ALT
url	http://link.springer.com/article/10.1186/s41065-020-00136-y
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Relationship between circulating miR-132 and non-alcoholic fatty liver disease in a Chinese population

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