Andrographolide attenuates synovial inflammation of osteoarthritis by interacting with tumor necrosis factor receptor 2 trafficking in a rat model

Andrographolide attenuates synovial inflammation of osteoarthritis by interacting with tumor necrosis factor receptor 2 trafficking in a rat model

Background: Synovial inflammation plays a major role in the pathogenesis of osteoarthritis (OA). This study investigated the effect of andrographolide (Andro) on synovial inflammation mediated by tumor necrosis factor-alpha receptor 2 (TNFR2) trafficking and its utility in attenuating OA progression...

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Bibliographic Details
Main Authors: Rongliang Wang, Jiawei Li, Xingquan Xu, Jia Xu, Huiming Jiang, Zhongyang Lv, Rui Wu, Ziying Sun, Wenjie Guo, Yang Sun, Shiro Ikegawa, Qing Jiang, Dongquan Shi
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Journal of Orthopaedic Translation
Subjects:
Andrographolide
TNFR2 trafficking
NF-κB
Synovial inflammation
OA treatment
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X21000322

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http://www.sciencedirect.com/science/article/pii/S2214031X21000322

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