Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival
In yeast, the phosphatase Cdc14 controls mitotic exit. Here the authors show that mammalian CDC14B antagonizes CDK1, to keep the deubiquitinase USP9X unphosphorylated and inactive, and that Wilms’ tumor protein 1 is a substrate for active USP9X that directs mitosis-specific transcription to regulate...
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Nature Publishing Group
2020-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15059-5 |
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doaj-bd16efa5decb42a998a0892197a135452021-05-11T09:09:38ZengNature Publishing GroupNature Communications2041-17232020-03-0111111210.1038/s41467-020-15059-5Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survivalMichael Dietachmayr0Abirami Rathakrishnan1Oleksandra Karpiuk2Felix von Zweydorf3Thomas Engleitner4Vanesa Fernández-Sáiz5Petra Schenk6Marius Ueffing7Roland Rad8Martin Eilers9Christian Johannes Gloeckner10Katharina Clemm von Hohenberg11Florian Bassermann12Department of Medicine III, Klinikum rechts der Isar, Technical University of MunichDepartment of Medicine III, Klinikum rechts der Isar, Technical University of MunichDepartment of Medicine III, Klinikum rechts der Isar, Technical University of MunichGerman Center for Neurodegenerative Diseases (DZNE)TranslaTUM, Center for Translational Cancer Research, Technical University of MunichDepartment of Medicine III, Klinikum rechts der Isar, Technical University of MunichDepartment of Medicine III, Klinikum rechts der Isar, Technical University of MunichUniversity of Tübingen, Center for Ophthalmology, Institute for Ophthalmic ResearchTranslaTUM, Center for Translational Cancer Research, Technical University of MunichTheodor Boveri Institute, Department of Biochemistry and Molecular Biology, Biocenter, University of WürzburgGerman Center for Neurodegenerative Diseases (DZNE)Department of Medicine III, Klinikum rechts der Isar, Technical University of MunichDepartment of Medicine III, Klinikum rechts der Isar, Technical University of MunichIn yeast, the phosphatase Cdc14 controls mitotic exit. Here the authors show that mammalian CDC14B antagonizes CDK1, to keep the deubiquitinase USP9X unphosphorylated and inactive, and that Wilms’ tumor protein 1 is a substrate for active USP9X that directs mitosis-specific transcription to regulate mitotic survival.https://doi.org/10.1038/s41467-020-15059-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Michael Dietachmayr Abirami Rathakrishnan Oleksandra Karpiuk Felix von Zweydorf Thomas Engleitner Vanesa Fernández-Sáiz Petra Schenk Marius Ueffing Roland Rad Martin Eilers Christian Johannes Gloeckner Katharina Clemm von Hohenberg Florian Bassermann |
| spellingShingle |
Michael Dietachmayr Abirami Rathakrishnan Oleksandra Karpiuk Felix von Zweydorf Thomas Engleitner Vanesa Fernández-Sáiz Petra Schenk Marius Ueffing Roland Rad Martin Eilers Christian Johannes Gloeckner Katharina Clemm von Hohenberg Florian Bassermann Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival Nature Communications |
| author_facet |
Michael Dietachmayr Abirami Rathakrishnan Oleksandra Karpiuk Felix von Zweydorf Thomas Engleitner Vanesa Fernández-Sáiz Petra Schenk Marius Ueffing Roland Rad Martin Eilers Christian Johannes Gloeckner Katharina Clemm von Hohenberg Florian Bassermann |
| author_sort |
Michael Dietachmayr |
| title |
Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival |
| title_short |
Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival |
| title_full |
Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival |
| title_fullStr |
Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival |
| title_full_unstemmed |
Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival |
| title_sort |
antagonistic activities of cdc14b and cdk1 on usp9x regulate wt1-dependent mitotic transcription and survival |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-03-01 |
| description |
In yeast, the phosphatase Cdc14 controls mitotic exit. Here the authors show that mammalian CDC14B antagonizes CDK1, to keep the deubiquitinase USP9X unphosphorylated and inactive, and that Wilms’ tumor protein 1 is a substrate for active USP9X that directs mitosis-specific transcription to regulate mitotic survival. |
| url |
https://doi.org/10.1038/s41467-020-15059-5 |
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