Serum from Chronic Hepatitis B Patients Promotes Growth and Proliferation via the IGF-II/IGF-IR/MEK/ERK Signaling Pathway in Hepatocellular Carcinoma Cells

Serum from Chronic Hepatitis B Patients Promotes Growth and Proliferation via the IGF-II/IGF-IR/MEK/ERK Signaling Pathway in Hepatocellular Carcinoma Cells

Background/Aims: Chronic hepatitis B virus (HBV) infection (CHB) plays a central role in the etiology of hepatocellular carcinoma (HCC). Emerging evidence implicates insulin-like growth factor (IGF)-II as a major risk factor for the growth and development of HCC. However, the relationship between HB...

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Bibliographic Details
Main Authors: Yuanyuan Ji, Zhidong Wang, Haiyan Chen, Lei Zhang, Fei Zhuo, Qingqing Yang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Hepatocellular carcinoma (HCC)
Hepatitis B virus (HBV)
Insulin-like growth factor-II (IGF-II)
Growth
Proliferation
Online Access:https://www.karger.com/Article/FullText/489744

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