Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice

Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice

Abstract Background Undoubtedly, neuroinflammation is a major contributor to Alzheimer’s disease (AD) progression. Neuroinflammation is characterized by the activity of brain resident glial cells, in particular microglia, but also by peripheral immune cells, which infiltrate the brain at certain sta...

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Bibliographic Details
Main Authors: M. S. Unger, P. Schernthaner, J. Marschallinger, H. Mrowetz, L. Aigner
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
Microglia
TMEM119
Macrophages
T-cells
Online Access:http://link.springer.com/article/10.1186/s12974-018-1304-4

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