Protein stability and dynamics modulation: the case of human frataxin.

Protein stability and dynamics modulation: the case of human frataxin.

Frataxin (FXN) is an α/β protein that plays an essential role in iron homeostasis. Apparently, the function of human FXN (hFXN) depends on the cooperative formation of crucial interactions between helix α1, helix α2, and the C-terminal region (CTR) of the protein. In this work we quantitatively expl...

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Bibliographic Details
Main Authors: Ernesto A Roman, Santiago E Faraj, Mariana Gallo, Andres G Salvay, Diego U Ferreiro, Javier Santos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3458073?pdf=render

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