Combination treatment of low fluence photodynamic therapy and intravitreal ranibizumab for choroidal neovascular membrane secondary to angioid streaks in Paget′s disease - 12 month results

• Main Authors: Varsha V Prabhu, Rodney J Morris, Parag K Shah, V Narendran
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2011-01-01
• Series: Indian Journal of Ophthalmology
• Subjects: Lymphoma; mucosa-associated lymphoid tissue; radiotherapy; Boston ocular surface prosthesis; India; keratoconus; scleral contact lens; Stevens-Johnson syndrome; Laser in-situ keratomileusis; post-radial keratotomy laser in-situ keratomileusis; radial keratotomy; Cataract; erythrocytes; galactose; glutathione; lens; Keratitis; keratomycosis; nonpigmented fungi; outcomes; pigmented fungi; Angiotensin-converting enzyme; antinuclear antibody; laboratory investigation; retinal vasculitis; Anterior segment optical coherence tomogram; corneal edema; Descemet′s membrane detachment; intraocular surgery; Intravitreal ranibizumab; Paget′s disease; subfoveal choroidal neovascular membrane
• Online Access: http://www.ijo.in/article.asp?issn=0301-4738;year=2011;volume=59;issue=4;spage=306;epage=308;aulast=Prabhu

Angioid streaks also called Knapp striae are small breaks in the Bruch′s membrane and have been reported with a host of systemic diseases. Rupture of streaks or development of secondary choroidal neovascular membrane (CNVM) carries a dismal visual prognosis. We report the successful treatment of CNVM secondary to Paget′s disease using low fluence photodynamic therapy (PDT) and intravitreal ranibizumab.