The Contribution of Co-signaling Pathways to Anti-malarial T Cell Immunity

The Contribution of Co-signaling Pathways to Anti-malarial T Cell Immunity

Plasmodium spp., the causative agent of malaria, caused 212 million infections in 2016 with 445,000 deaths, mostly in children. Adults acquire enough immunity to prevent clinical symptoms but never develop sterile immunity. The only vaccine for malaria, RTS,S, shows promising protection of a limited...

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Bibliographic Details
Main Authors: Rebecca Faleiro, Deshapriya S. Karunarathne, Joshua M. Horne-Debets, Michelle Wykes
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
malaria
immunity
inhibitory receptors on T cells
stimulatory receptors on T cells
Immuno-therapy
chronic malaria
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02926/full

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